Antidiarrheal Effectiveness Test of Noni Leaf Infusion (Morinda citrifolia L.) Against Male White Mice (Mus musculus) Induced by Oleum ricini

Putri Maulidya Achsani; Nuri Nuri; Shinta Mayasari

doi:10.35316/icorhestech.v1i1.5699

Putri Maulidya Achsani
Nuri Nuri
Shinta Mayasari

10.35316/icorhestech.v1i1.5699

Abstrak

Diarrhea is a disease of the digestive system which is defined as defecation more than three times a day which is characterized by changes in the shape and consistency of the stool. The results of the Indonesian Nutritional Status survey (2020) stated that the prevalence of diarrhea was 9.8%. One of the plants that has antidiarrheal properties is noni leaves (Morinda citrifolia L.) with the compounds contained in noni leaves being flavonoids. This study aims to determine the effective dose of noni leaf infusion as antidiarrhea in male white mice (Mus musculus) induced by oleum ricini. The research design used was laboratory experimental using male white mice (Mus musculus) as test animals by dividing the negative control, positive control, noni leaf infusion treatment groups with infusion doses of 100, 200, and 400 mg/KgBW. Results of observations of the antidiarrheal effectiveness of noni leaf infusion at the most effective dose was a dose of 400 mg/KgBW with the initial parameters of diarrhea the average frequency of diarrhea was five times with the average weight of feces is 0.53 grams and the average duration of diarrhea is 90.25 minutes. The data obtained were analyzed by ANOVA at a confidence level of 95%.Noni leaf infusion (Morinda citrifolia L.) has effectiveness as an antidiarrhea in male white mice (Mus musculus) induced by oleum ricini with the dose 400 mg/KgBW.

Referensi

Ambari, Y. 2018. Uji Aktivitas Antidiare Ekstrak Etanol Daun Salam (Eugenia polyantha Wight) Pada Mencit Putrih (Mus musculus) Jantan Galur Balb-C. Journal of Pharmaceutical Care Anwar Medika. 1(1): 25-33.
Badan Penelitian dan Pengembangan Kesehatan. 2019. Laporan Nasional Riskasdes 2018. Kementrian Kesehatan Republik Indonesia (Kemenkes RI). Jakarta.
Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. 2022. Rencana Aksi Program tahun 2020-2024. Kementrian Kesehatan Republik Indonesia (Kemenkes RI). Jakarta.
Manek, M. S., Klau, M. E., Beama, C. A. 2020. Uji Efektivitas Antidiare Ekstrak Etanol Daun Sirih (Piper betle L.) Pada Tikus Putih Jantan Galur Wistar Yang Diinduksi Oleum Ricini. Chmk Pharmaceutical Scientific Journal. 3(2): 147-151.
Mayasari, Shinta. 2020. The Examination Of Salam leaf Ethanolic Ekstract (Syzygium polyanthum)(Wight) In Mice. Journal Urbangreen. 1(2): 50-55.
Meliala, L., Niisaa, K. 2022. Uji Efektivitas Antidiare Ekstrak Etanol Daun Binara (Artemisia vulgaris L.) Terhadap Mencit Putih (Mus musculus) Dengan Menggunakan Induksi Oleum Ricini. Best Journal (Biology Education Science & Technology). 5(1): 387-392.
Muthia, R., Musfirah, Y., Candrakirana, S. 2019. Uji Aktivitas Antidiare Ekstrak Etanol Daun Mengkudu (Morinda citrifolia L.) Terhadap Mencit Galur Balb/C Yang Diinduksi Bakteri Salmonella sp. Jurnal Borneo Journal of Pharmascientech. 3(1): 1-8.
Nugrahani, A., Islami, L., dan Khumaidi, A. 2021. Aktivitas Antidiare Ekstrak Etanol Daun Jarak Merah (Jatropha gossypifolia) Pada Mencit Yang Diinduksi Bakteri Escherichia coli. Jurnal Veteriner. 22(3): 414-421.
Pongoh, G., Hariyadi., Maarisit, W., Tapehe, Y. 2020. Uji Efektivitas Ekstrak Kulit Buah Jeruk Bali Citrus Maxima Sebagai Antidiare Pada Tikus Putih Jantan Rattus Norvegicus. Jurnal Biofarmasetikal Tropis. 3(1): 39-45.
Purwaningdyah, Y., Widyaningsih, T., dan Wijayanti, N. 2015. Efektivitas Ekstrak Biji Pepaya (Carica papaya L.) Sebagai Antidiare Pada Mencit Yang Diinduksi Salmonella typhimurium. Jurnal Pangan dan Agroindustri. 3(4): 1283-1293.
Rambe, R., Depiana Gultom, E., Sylvia Br Ginting, O., dan Diana, S. 2021. Uji Efektivitas Antidiare Ekstrak Etanol Daun Mengkudu (Morinda citrifolia L.) Terhadap Mencit Jantan Dengan Metode Transit Intestinal. Forte Journal. 1(1): 1-11.
Sembiring, P., Sembiring, T. R. 2021. Uji Efektivitas Antidiare Ekstrak Etanol Daun Gelugur (Garnicia atrovidiris griff ex T anderson) Terhadap Tikus Jantan Putih (Rattus norvegicus) Dengan Loperamide Sebagai Pembanding. Jurnal Penelitian Farmasi Herbal. 3(2): 36-43.
Simatupang, O. C., Abidjulu, J., Siagian, K. 2017. Uji daya hambat ekstrak daun mengkudu (Morinda citrifolia L.) terhadap pertumbuhan Candida albicans secara in vitro. Jurnal e-GiGi. 5(1): 1-6.
Suliska, N., Evrianto, T., Herlinda. 2019. Efek Antidiare Infusa Daun Senggani (Melastoma malabathricum L.) Pada Mencit Jantan Galur Swiss Webster Yang Di Induksi Oleum Ricini. Jurnal Ilmu Kefarmasian Indonesia. 17(2): 126-131.
Suwarni, E., Cahyaningsih, E., Sandhi, E., dan Yuda, K. 2016. Uji Efek Analgesik Infusa Daun Mengkudu (Morinda citrifolia L.) Pada Mencit Jantan (Mus musculus. Jurnal Ilmiah Medicamento. 2(1): 6-11.
Thahir, Z., Afni Azizah, N. 2017. Uji Efek Antidiare Ekstrak Daun Mengkudu (Morinda citrifolia L) Pada Mencit (Mus musculus). Skripsi. Program Studi D3 Farmasi Yamasi Makassar.
Usman, Y., Iriawan, R., Rosita, T., Lusiana, M., Kosen, S., Kelly, M., Forsyth, S., Rao, C. 2019. Indonesia’s Sample Registration System in 2018: A Work in Progress. Journal of Population and Social Studies. 27(1): 39-52.
Widyaningsih, T., dan Safitri, N. 2014. Efek Antidiare Minuman Fungsional Jelly Drink Cincau Hitam (Mesona palustris BL.). Jurnal Agroteknologi. 8(1): 74-84.