Studi Interaksi Obat Antihipertensi Pasien Rawat Inap

Abstract

Hipertensi merupakan suatu keadaan peningkatan tekanan darah sistolik lebih dari 140 mmHg dan
tekanan darah diastolik lebih dari 90 mmHg pada dua kali pengukuran dengan selang waktu 5 menit dalam
keadaan tenang. Hipertensi sering diikuti dengan penyakit lain. Sehingga pengobatan hipertensi sering
dikombinasikan bersama obat lain dan berpotensi meningkatkan terjadinya interaksi obat. Penelitian ini
bertujuan untuk mengidentifikasi tingkat keparahan interaksi obat antihipertensi pada pasien rawat jalan
RSUD Abdoer Rahem Situbondo periode Juli sampai Desember 2022. Penelitian ini termasuk penelitian
observasi (survei), jenis penelitian survei analitik dan data diambil secara retrospektif. Jenis analisis data
adalah analisis univariat dan data dikelola secara teoritik menggunakan Stockley Drug Interaction dan review
aplikasi drugs.com. Dari 135 rekam medis yang memenuhi kriteria inklusi, diperoleh 81 % berpotensi
mengalami interaksi obat dan 19 % tidak mengalami interaksi obat. Antihipertensi yang sering diresepkan dan
paling besar menimbulkan interaksi obat adalah candesartan (37,8 %). Dari 135 rekam medis, ditemukan 422
kasus tingkat keparahan interaksi obat, dengan tingkat keparahan minor sebesar 21,5 %, tingkat keparahan
moderat sebesar 64,4% dan tingkat keparahan mayor sebesar 13,9 %.

ABSTRACT
Hypertension is a condition of increasing systolic blood pressure of more than 140 mmHg and
diastolic blood pressure of more than 90 mmHg on two measurements with an interval of 5 minutes in a calm
state. Hypertension is often followed by other diseases. So that the treatment of hypertension is often
combined with other drugs and has the potential to increase the occurrence of drug interactions. This study
aims to identify the severity of antihypertensive drug interactions in outpatients at RSUD Abdoer Rahem
Situbondo from July to December 2022. This study was an observational study (survey), an analytic survey
study type, and data were collected retrospectively. The type of data analysis was univariate analysis and the
data was managed theoretically using Stockley Drug Interaction and a drug.com application review. Of the
135 medical records that met the inclusion criteria, it was found that 81% had the potential to experience
drug interactions and 19% did not experience drug interactions. The antihypertensive that is often prescribed
and causes the greatest drug interactions is candesartan (37.8%). From 135 medical records, 422 cases of
drug interaction severity were found, with a minor severity of 21.5%, a moderate severity of 64.4% and a
major severity of 13.9%.